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The Pioneering Vision of PAD 20/20: A Crusade Against Alzheimer's

In 1992, a relatively unknown yet monumental editorial coined the "Five-Five and Ten-Ten plan" to defeat Alzheimer's disease (AD). It served as a clarion call for mobilizing U.S. national research and development resources against an escalating public health threat. The ambitious plan set forth dual objectives: to develop interventions capable of delaying AD symptoms by five years within a half-decade, followed by a ten-year-target to further delay symptoms by a decade.


As Alzheimer’s cast a lengthening shadow across the nation’s aging population, the Alzheimer’s Study Group (ASG) emerged in 2007, empowered by the U.S. Congressional Task Force to engineer a National Strategic Plan against America’s mounting Alzheimer’s crisis. Spearheaded by heavyweights such as former Speaker Newt Gingrich and former U.S. Senator Bob Kerrey, the ASG's composition of national leaders symbolized a formidable alliance straddling government, advocacy, and academia, united against a common foe.


Parallel to the ASG’s inception, the Leon Thal Symposia began fabricating a collective intelligence from over 70 global leaders to galvanize dementia therapy research and celebrate Dr. Leon Thal's dynamic AD research legacy. These synergistic forces charted the course for what would become PAD 20/20—a non-profit organization dedicated to erecting a scientific bulwark for Alzheimer's prevention.



PAD 20/20's founders envisioned a world where Alzheimer’s could be preemptively challenged. Their strategic plan wasn't just a roadmap; it was a promise of proactive resilience: expand research, cultivate intervention strategies, and breed a nuanced understanding of the socio-economic intricacies linked to neurodegenerative diseases.

The campaign's long-term goal to halve the prevalence of disorders such as Alzheimer's within the 2020s was based on a simple yet transformative concept: modestly delaying the onset of AD could precipitate a drastic decline in both disease incidence and associated costs. PAD 20/20 wasn't merely a preventative campaign; it was a paradigm shift towards an age of anticipation rather than reaction—a crusade with the foresight to set a new precedent for how society confronts the inevitability of aging and illness.

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